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Zopiclone belongs to the class of medications called sedative-hypnotics. It is used for the short-term and symptomatic relief of sleep disturbances. Zopiclone can help with difficulty falling asleep, frequent wake-ups during the night, or early morning awakenings. Zopiclone should usually not be taken for more than 7 to 10 consecutive days. It should be used only by people for whom disturbed sleep results in problems functioning during the day.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Before taking zopiclone

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking zopiclone it is important that your doctor knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have any breathing problems, or if you have sleep apnoea (a problem where you stop breathing for short periods at night).
  • If you have a condition called myasthenia gravis, or if you have any other condition causing muscle weakness, especially if this causes breathing difficulties.
  • If you have ever had a drug addiction.
  • If you have a mental health problem.
  • If you have any problems with the way your liver works, or any problems with the way your kidneys work.
  • If you have ever had an allergic reaction to a medicine.
  • If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.

Dosage and Administration

Treatment should be as short as possible and should not exceed four weeks including the period of tapering off. Extension beyond the maximum treatment period should not take place without re-evaluation of the patient’s status. The product should be taken just before retiring for the night.

Treatment Duration:

Transient insomnia: 2 to 5 days

Short-term insomnia: 2 to 3 weeks

Chronic insomnia: long term treatment should only be considered after consultation with a specialist.


7.5mg by oral administration shortly before retiring for a maximum of 2 - 4 weeks. This dose should not be exceeded.

Depending on clinical response, the dose may be lowered to 3.75mg. Zopiclone is not recommended for long term use (i.e periods of more than 4 weeks).

If physical dependence is suspected treatment should be withdrawn gradually.

Treatment of patients with impaired liver function or chronic respiratory insufficiency should be initiated on a dose of 3.75mg and if necessary increased to 7.5mg.

Although in cases of renal insufficiency no accumulation of zopiclone or its metabolites has been detected, it is recommended that patients with impaired renal function start treatment with a dose of 3.75mg.


3.75mg is advisable initially; depending on effectiveness and tolerance, the dose can be increased to 7.5mg.