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This medication is used to help relieve moderate to moderately severe pain. Tramadol is similar to narcotic analgesics. It works in the brain to change how your body feels and responds to pain.

There are many different forms, strengths and brands of tramadol. Some forms and brands of tramadol start working quickly to ease pain. Others release the tramadol they contain more slowly over several hours to provide a constant and more-even pain control - these are called 'modified-release' and often have 'XL', 'SR' or '24hr' after their brand name.

Dosing Considerations

It is not recommended for minor pain that may be treated adequately through lesser means where benefit does not outweigh the possible opioid-related side effects.

It can be administered without regard to food.

Do not co-administer ULTRAM® tablets with other tramadol-containing products.

Due to the differences in pharmacokinetic properties, ULTRAM® tablets are not interchangeable with tramadol extended-release formulations.

The maximum recommended dose of ULTRAM® should not be exceeded.

Recommended Dose And Dosage Adjustment

Good pain management practice dictates that the dose be individualized according to patient need using the lowest beneficial dose. Studies with tramadol in adults have shown that starting at the lowest possible dose and titrating upward will result in fewer discontinuations and increased tolerability.

Adults (18 Years of Age and Over)

For patients with moderate to moderately severe chronic pain not requiring rapid onset of analgesic effect, the tolerability of ULTRAM® can be improved by initiating therapy with the following titration regimen: ULTRAM® should be started at 25 mg/day (half ULTRAM® scored tablet) qAM and titrated in 25 mg increments as separate doses every 3 days to reach 100 mg/day (25 mg q.i.d.). Thereafter the total daily dose may be increased by 50 mg as tolerated every 3 days to reach 200 mg/day (50 mg q.i.d.) as shown in Table 1.3 below.