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PERCOCET is indicated for the relief of moderate to moderately severe pain.

Percocet is a pain medication that combines both narcotic and non-narcotic pain drugs: oxycodone and acetaminophen. In general, it takes a significant amount of oxycodone in Percocet to be fatal – several times more than the normal dose. In fact, overdose risk increases if you are getting high off Percocet instead of using Percocet for medical reasons. And note here that acetaminophen must be taken exactly as directed to avoid serious health problems. How long Percocets stay in system is about a few days, due to the relatively short half life of oxycodone. But in terms of too much Percocet, acetaminophen is really the main cause of concern.

Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. PERCOCET tablets are given orally.

Initial Dose

One tablet or capsule (acetaminophen/oxycodone 325 mg-5 mg), (acetaminophen/oxycodone 500 mg-5 mg), or (acetaminophen/oxycodone 500 mg-10 mg) orally every 6 hours as needed, or 5 mL (acetaminophen/oxycodone 325 mg-5 mg) oral elixir every 6 hours as needed.

Alternatively, the following dosage combinations may be used:

  • one or two tablets of acetaminophen-oxycodone 300 mg-2.5 mg every six hours (maximal daily dose is 12 tablets), or
  • one tablet of acetaminophen-oxycodone 300 mg-5 mg every six hours (maximal daily dose is 12 tablets), or
  • one tablet of acetaminophen-oxycodone 300 mg-7.5 mg every six hours (maximal daily dose is 8 tablets), or
  • one tablet of acetaminophen-oxycodone 300 mg-10 mg every six hours (maximal daily dose is 6 tablets), or
  • one or two tablets of acetaminophen-oxycodone 400 mg-2.5 mg every six hours (maximal daily dose is 10 tablets), or
  • one tablet of acetaminophen-oxycodone 400 mg-5 mg every six hours (maximal daily dose is 10 tablets), or
  • one tablet of acetaminophen-oxycodone 400 mg-7.5 mg every six hours (maximal daily dose is 8 tablets), or
  • one tablet of acetaminophen-oxycodone 400 mg-10 mg every six hours (maximal daily dose is 6 tablets) as needed.